Protein Details: Amiloride-sensitive sodium channel subunit beta-2
Protein ID
ICDB_Pro_0180
Protein Name
Amiloride-sensitive sodium channel subunit beta-2
Gene Name
scnn1b-b
Organism
Xenopus laevis (African clawed frog)
Length
646 amino acids
AlphaFoldDB
AF-O13262-F1-model_v4.pdb
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water; which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis; but also in airway surface liquid homeostasis; which is important for proper clearance of mucus.
Sequence
MIQGKLKRLKRYFTRALHRIQKGPGYTYKELLVWFCDNTNTHGPKRIIKEGPKKRVMWFILTLVFAGLVFWQWGLLILTYLSYGVSVSLSIGFKTMEFPAVTVCNTNPYKYSRVKPLLKDLDELVATALDRIQYSSQTQANTFTYNNTRQNVTLDPALWNHIPLVVIDENDPSNPVIHNIFDNSVFYSKNNLLRNSSEDQTSYAQRYKVAMKLCTNNNTQCVYRNFTSGVQALREWYLLQLSIIFSNVPLSDRVDMGFKAEDLILTCLFGGQPCSYRNFTHIYDADYGNCYIFNWGQEGDDTMSSANPGADFGLKLVLDIEQDEYLPFLQTTAAARLILHQQRSFPFVKDLGIYAKPGTETSIAVLVDQLQQMEAPYSSCTVNGSDIPVQNLYEEFNSSYSIQSCLRSCYQEEMVKTCKCAHYQYPLPNGSEYCTNNKHPDWVPCYYGLRDSVAIRENCISLCQQPCNDTHYKMVISMADWPSAGAEDWIFHVLSYEKDSSYDITVNRNGIIRLNIYFQEFNYRSISESEATNVVWLLSNLGGQFGFWMGGSVLCIIEFGEIIIDCMWITILKLLAWIRNRRQRRQRPQYADPPPTVSELVEAHTNPGFQHDDGNHVTEDIPGTPPPNYDSLRVNTIEPVSSDEEN
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
10.1073/pnas.94.11.5949
RefSeq
NP_001081525.1